Potassium Iodide → 1-(Dimethylamino)cyclopropaneacetonitrile
Reaction equation
Cl.Cl[CH2:3][C:4]1([N:7]([CH3:9])[CH3:8])[CH2:6][CH2:5]1.[C-:10]#[N:11].[Na+].[I-].[K+].C(=O)([O-])[O-].[Na+].[Na+].[Cl-].[Na+]>CS(C)=O>[CH3:8][N:7]([CH3:9])[C:4]1([CH2:3][C:10]#[N:11])[CH2:6][CH2:5]1Participants
7
Reactant 5
Product 1
Reagents, catalysts & solvents 1
Procedure
30.3 g of the compound obtained in Step 1 are added to a solution of 43 g of sodium cyanide and 3.5 g of potassium iodide in 400 ml of dimethyl sulphoxide. After stirring for 20 hours at ambient temperature, 490 ml of 10% aqueous sodium carbonate solution and then sodium chloride are added. The mixture is extracted with ether. After conventional treatment of the organic phases, chromatography over silica gel allows the expected product to be isolated.
Workup
- extractionThe mixture is extracted with ether
- customto be isolated
Sources & evidence
- ORD record
- ord-21e5b1bc66e0456e9622a0f123b7d193
- Source dataset
- uspto-grants-2005_09
- Patent number
- US06943184B2
Reaction notes
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