HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (4 Naphth-1-ylpiperid 1-yl)acetonitrile hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Bromoacetonitrile | HCID 11534 | — |
| Reactant | 4-(Naphth-1-yl)piperidine hydrobromide | HCID 19096220 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | (4 Naphth-1-ylpiperid 1-yl)acetonitrile hydrochloride | HCID 19784336 | 91.83% |
Reaction Steps
5 g of the compound from Example 3, 7.088 g of potassium carbonate and 2.259 g of bromoacetonitrile in 200 ml of acetone are stirred for 10 hours under reflux and a stream of nitrogen. After filtering and evaporation of the filtrate, the residue obtained is treated with an ethanolic solution of hydrogen chloride to give 4.5 g of the expected hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05242933 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-c23b7acaed9b4fbbb249c32c51607fe4 |
| Source note | uspto-grants-1993_09 |