HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromoquinoline → 1-Methyl-4-(quinolin-3-yl)piperidin-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromoquinoline | HCID 21413 | — |
| Reactant | 1-Methyl-4-piperidone | HCID 74049 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 1-Methyl-4-(quinolin-3-yl)piperidin-4-ol | HCID 19096203 | 53.84% |
Reaction Steps
95.01 g of 3-bromoquinoline were treated with 200 ml of a 2.5M solution of butyllithium in hexane and 51.62 g of 1-methylpiperid-4-one in accordance with the procedure described in Stage A of Example 1, in order to obtain the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05242933 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-dbcee54bd5e04652bd5d90e8abadadc6 |
| Source note | uspto-grants-1993_09 |