HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Celecoxib
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 4-Hydrazinylbenzenesulfonamide hydrochloride | HCID 2794567 | — |
| Reactant | 1,1,1-Trifluoro-4-(o-tolyl)but-3-yn-2-one | HCID 22395294 | — |
| Solvent | Water | HCID 962 | — |
| Product | Celecoxib | HCID 2662 | — |
Reaction Steps
A solution of 1,1,1-trifluoro-4-(methylphenyl)-3-butyn-2-one (3, 10 mmol) in ethanol (100 mL) is refluxed with 4-sulfamylphenyl hydrazine hydrochloride (4, 12 mmol) for 4 h. The reaction mixture is cooled and diluted with water. The precipitated crude 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide is filtered and recrystallized.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06706927B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-bd38d68fc917443f9c7154a1c559e206 |
| Source note | uspto-grants-2004_03 |