Water → 2-Acetamido-5-bromopyridine

HRID 49719

Reaction equation

HRID 49719 reaction equation
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][N:10]=1.O>C(O)(=O)C>[Br:15][C:12]1[CH:13]=[CH:14][C:9]([NH:8][C:5](=[O:7])[CH3:6])=[N:10][CH:11]=1

Participants

5

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 706222-Amino-5-bromopyridine

Product 1

HCID 2930972-Acetamido-5-bromopyridine

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Acetic anhydride (27.4 mL) was added to a stirred suspension of 2-amino-5-bromopyridine (10.0 g) in acetic acid (40 mL). The mixture was heated at reflux for 4 hours, then cooled to room temperature and then poured into water (200 mL). The resulting solid was collected, washed three times with water (300 ml) and then dried in vacuo at 70° C., affording the title compound as a white solid (10.9 g).

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 4 hours
  3. customThe resulting solid was collected
  4. washwashed three times with water (300 ml)
  5. customdried in vacuo at 70° C.

Sources & evidence

ORD record
ord-a8376e32560e4ae2b4a581d3d9db980c
Source dataset
uspto-grants-2004_03
Patent number
US06706738B2

Linked notes

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