HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Iodobenzoic acid → 1-(6-ethoxy-2-pyridinyl)-3-methyl-1H-pyrazol-5-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Iodobenzoic acid | HCID 6941 | — |
| Reactant | 2-Chloro-6-ethoxypyridine | HCID 98563 | — |
| Reactant | 6-Ethoxy-2-hydrazinopyridine | HCID 22320339 | — |
| Reactant | 1-(6-ethoxy-2-pyridinyl)-3-methyl-1H-pyrazol-5-ylamine | HCID 22320358 | — |
| Product | 4-Chloro-1-(6-ethoxy-2-pyridinyl)-3-methyl-1H-pyrazolo[3,4-b]quinoline | HCID 22320331 | — |
| Product | 1-(6-ethoxy-2-pyridinyl)-3-methyl-1H-pyrazol-5-ylamine | HCID 22320358 | 36% |
Reaction Steps
Following the procedure described in Reference Example 2-4, 1-(6-ethoxy-2-pyridinyl)-3-methyl-1H-pyrazol-5-ylamine was prepared from 6-ethoxy-2-hydrazinopyridine which was prepared from 2-chloro-6-ethoxypyridine following the method described in Reference Example 2-2. Subsequently, following the methods described in Reference Example 2-5 and Example 2-1, the title compound was prepared from o-iodobenzoic acid and 1-(6-ethoxy-2-pyridinyl)-3-methyl-1H-pyrazol-5-ylamine (36% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949648B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-924538d461a647ff98332d649a44b220 |
| Source note | uspto-grants-2005_09 |