2-Amino-3,3-dimethylbutanamide → (2R)-2-Amino-3,3-dimethylbutanamide

HRID 498088Notes

Reaction equation

HRID 498088 reaction equation
[NH2:1][CH:2]([C:7]([NH2:9])=[O:8])[C:3]([CH3:6])([CH3:5])[CH3:4]>O>[NH2:1][C@@H:2]([C:7]([NH2:9])=[O:8])[C:3]([CH3:6])([CH3:5])[CH3:4]

Participants

3

Reactant 1

HCID 34964442-Amino-3,3-dimethylbutanamide

Product 1

HCID 10197708(2R)-2-Amino-3,3-dimethylbutanamide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In accordance with the process described in JP Patent Application Laying Open (Kokai) No. 62-55097, Enterobacter cloacae N-7901 (FERM BP-873) was cultured. 1 L of culture solution was centrifuged, and the wet cells were then suspended in distilled water to prepare a 800 g cell suspension. 200 g of D,L-tert-leucine amide was dissolved in this suspension, and the solution was then allowed to react at 40° C. for 52 hours. After the reaction, cells were removed by centrifugation and 970 g of an aqueous solution containing 10% by mass each of L-tert-leucine and D-tert-leucine amide was obtained.

Workup

  1. customto prepare a 800 g cell suspension
  2. customto react at 40° C. for 52 hours
  3. customAfter the reaction, cells
  4. customwere removed by centrifugation and 970 g of an aqueous solution
  5. additioncontaining 10% by mass each of L-tert-leucine

Sources & evidence

ORD record
ord-a6931ace804f4de0aea194ee160ea841
Source dataset
uspto-grants-2005_09
Patent number
US06949658B2

Reaction notes

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