(S)-(+)-2-Phenylglycine amide → 2-Amino-2-phenylacetamide

HRID 498090

Reaction equation

HRID 498090 reaction equation
[CH:1]1[CH:6]=[CH:5][C:4]([C@H:7]([NH2:11])[C:8]([NH2:10])=[O:9])=[CH:3][CH:2]=1>O>[CH:1]1[CH:2]=[CH:3][C:4]([CH:7]([NH2:11])[C:8]([NH2:10])=[O:9])=[CH:5][CH:6]=1

Participants

3

Reactant 1

HCID 729986(S)-(+)-2-Phenylglycine amide

Product 1

HCID 127912-Amino-2-phenylacetamide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In accordance with the process described in JP Patent Application Laying Open (Kokai) No. 62-55097, Enterobacter cloacae N-7901 (FERM BP-873) was cultured. This culture solution, 100 mL, was centrifuged, and the wet cells were then suspended in distilled water to prepare a 270 g cell suspension. D, L-phenylglycine amide, 30 g, was dissolved in this suspension, and the mixture was then allowed to react at 40° C. for 18 hours. After the reaction, cells were removed by centrifugation and 295 g of an aqueous solution containing 5.0% by mass each of L-phenylglycine and D-phenylglycine amide was obtained.

Workup

  1. customto prepare a 270 g cell suspension
  2. customto react at 40° C. for 18 hours
  3. customAfter the reaction, cells
  4. customwere removed by centrifugation and 295 g of an aqueous solution
  5. additioncontaining 5.0% by mass each of L-phenylglycine

Sources & evidence

ORD record
ord-6d343bb9ea194e9dab7172539ee081ee
Source dataset
uspto-grants-2005_09
Patent number
US06949658B2

Linked notes

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