Methyl 3-(pyridin-2-yl)benzoate → 3-Oxo-3-(3-pyridin-2-yl-phenyl)-propionic acid tert-butyl ester

HRID 498231Notes

Reaction equation

HRID 498231 reaction equation
CO[C:3](=[O:16])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)[CH:5]=1.[C:17]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])(=[O:19])[CH3:18].[Li]>>[C:21]([O:20][C:17](=[O:19])[CH2:18][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)[CH:5]=1)([CH3:24])([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 3364101Methyl 3-(pyridin-2-yl)benzoateHCID 86586795Lithium Tert-butyl Acetate

Product 1

HCID 694892013-Oxo-3-(3-pyridin-2-yl-phenyl)-propionic acid tert-butyl ester

Procedure

The title compond was prepared from 3-pyridin-2-yl-benzoic acid methyl ester [CAS-No. 98061-20-2] (9.42 g, 44.18 mmol) by treatment with lithium tert-butyl acetate according to general procedure K (method b). Obtained as a yellow oil (8.35 g).

Sources & evidence

ORD record
ord-d98e1616698147ef96b0090ae009be8d
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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