Carbamic acid,n-[2-amino-5-(dimethylamino)-4-(trifluoromethyl)phenyl]-,1,1-dimethylethyl ester → HCID 22317614, compound
Reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[NH2:21])(C)(C)C.C(O[C:28](=[O:46])[CH2:29][C:30]([C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([C:38]2[CH:43]=[C:42]([CH3:44])[N:41]=[C:40]([NH2:45])[N:39]=2)[CH:33]=1)=O)(C)(C)C>>[NH2:45][C:40]1[N:39]=[C:38]([C:34]2[CH:33]=[C:32]([C:30]3[CH2:29][C:28](=[O:46])[NH:21][C:9]4[CH:10]=[C:11]([C:17]([F:18])([F:19])[F:20])[C:12]([N:14]([CH3:16])[CH3:15])=[CH:13][C:8]=4[N:7]=3)[CH:37]=[CH:36][CH:35]=2)[CH:43]=[C:42]([CH3:44])[N:41]=1Participants
3
Procedure
The title compound was prepared from (2-amino-5-dimethylamino-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J1) (96 mg, 0.3 mmol) and 3-[3-(2-amino-6-methyl-pyrimidin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K45) (118 mg, 0.36 mmol) according to the general procedure M and subsequent treatment of the crude product according to the general procedure N. Obtained as a light yellow solid (31 mg).
Sources & evidence
- ORD record
- ord-9abfac16c5024994812225b83ec2102d