3-Hydroxybenzoic Acid → 3-Hydroxy-4-iodobenzoic acid

HRID 49918

Reaction equation

[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].[I:11]Cl>C(O)(=O)C>[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[I:11])[C:5]([OH:7])=[O:6]

Participants

Conditions

Temperature: 45 °C

Procedure

30.0 g (217 mmol) of 3-hydroxybenzoic acid was dissolved in 200 ml of acetic acid. 53.0 g (326 mmol) of iodine monochloride was added to the obtained solution at room temperature. They were stirred at 45° C. for 15 hours and then the solvent was evaporated under reduced pressure. The residue was washed with 500 ml of 1% aqueous sodium thiosulfate solution twice and with 500 ml of water twice and then dried to solid at 80° C. under reduced pressure to obtain the title compound.

Workup

customthe solvent was evaporated under reduced pressure
washThe residue was washed with 500 ml of 1% aqueous sodium thiosulfate solution twice
dry with materialwith 500 ml of water twice and then dried to solid at 80° C. under reduced pressure

Sources & evidence

ORD record: ord-e1eb3d62740b458ea1229145a6525f83
Source dataset: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06710056B2

Linked notes

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