3-Hydroxybenzoic Acid → 3-Hydroxy-4-iodobenzoic acid
Reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].[I:11]Cl>C(O)(=O)C>[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[I:11])[C:5]([OH:7])=[O:6]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 45 °C
Procedure
30.0 g (217 mmol) of 3-hydroxybenzoic acid was dissolved in 200 ml of acetic acid. 53.0 g (326 mmol) of iodine monochloride was added to the obtained solution at room temperature. They were stirred at 45° C. for 15 hours and then the solvent was evaporated under reduced pressure. The residue was washed with 500 ml of 1% aqueous sodium thiosulfate solution twice and with 500 ml of water twice and then dried to solid at 80° C. under reduced pressure to obtain the title compound.
Workup
- customthe solvent was evaporated under reduced pressure
- washThe residue was washed with 500 ml of 1% aqueous sodium thiosulfate solution twice
- dry with materialwith 500 ml of water twice and then dried to solid at 80° C. under reduced pressure
Sources & evidence
- ORD record
- ord-e1eb3d62740b458ea1229145a6525f83
- Source dataset
- uspto-grants-2004_03
- Patent number
- US06710056B2
Reaction notes
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