O-Xylene → Ethyl 1-(pyridin-4-yl)piperidine-3-carboxylate

Participants

Reaction Conditions

Reaction Steps

A mixture of 5 g of ethyl nipecotate, 4.8 g of 4-chloropyridine hydrochloride, 6.6 g of triethylamine and 100 ml of xylene was stirred at 100° C. overnight. The reaction mixture was treated with ethyl acetate as the extracting solvent in an ordinary manner, and the obtained residue was purified by the silica gel chromatography (ethyl acetate/ethanol) to obtain the title compound.

Provenance & Evidence