2,6-Dichloro-4-nitrophenol → (7-(2,6-Dichloro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)(pyrrolidin-1-yl)methanone

Participants

Role	Name	HCID	Charge
Reactant	2,6-Dichloro-4-nitrophenol	HCID 12066	—
Reactant	(7-Chlorothieno[3,2-b]pyridin-2-yl)(pyrrolidin-1-yl)methanone	HCID 11173165	—
Reactant	7-(2-fluoro-4-nitrophenoxy)-N,N-dimethylthieno[3,2-b]pyridine-2-carboxamide	HCID 59424475	—
Product	(7-(2,6-Dichloro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)(pyrrolidin-1-yl)methanone	HCID 59424694	69%

Reaction Steps

Starting from the compound 139 and following the procedure described above for the synthesis of compound 6 (scheme 1, example 1) but replacing 2-fluoro-4-nitrophenol with 2,6-dichloro-4-nitrophenol, title compound 140 was obtained in 69% yield. LRMS (M+1) 438.0 (100%), 439.1 (20%), 440.1 (70%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07772247B2
Source dataset	uspto-grants-2010_08
ORD ID	ord-5e26d3efa8bf46d7bbaf674d75fe4a30
Source note	uspto-grants-2010_08