Tegafur → 5-Fluoro-1-(oxolan-2-yl)pyrimidine-2,4-dione;palladium

Participants

Reaction Steps

Pd was supported on TS-1 by suspending TS-1 (1.6% Ti, 20 grams) in deionized water (80 grams), in the presence of tetraamine palladium nitrate (5% Pd, 2.542 grams) at 80° C. for 24 hours. The solid was recovered by filtration under pressurized N2, washed with deionized water (150 mL, three times), dried under house vacuum at 50° C. overnight, and calcined at 150° C. for 4 hrs in 5% O2-95% N2 mixture. The resulting catalyst has 0.47 wt % Pd. Pd/TS-1 catalyst (2 grams) was then suspended in 75 wt % MeOH -25 wt % H2O (100 grams) and preactivated in a 100 cc/min gas flow (10% C3H6, 4% O2, and 4% H2) at 45 C. and 3 psig for 22 hours.

Provenance & Evidence