3-Chloro-2-methylaniline → N-(4-Bromo-3-chloro-2-methylphenyl)acetamide

HRID 501561

Reaction equation

HRID 501561 reaction equation
[Cl:1]C1C(C)=C(C=CC=1)N.C1(NC(=O)C)C2CCCCC=2C=CC=1.[Br:24][C:25]1[C:34]2CCC[CH2:30][C:29]=2[C:28]([NH:35][C:36](=[O:38])[CH3:37])=[CH:27][CH:26]=1>>[Br:24][C:25]1[CH:26]=[CH:27][C:28]([NH:35][C:36](=[O:38])[CH3:37])=[C:29]([CH3:30])[C:34]=1[Cl:1]

Participants

4

Reactant 3

HCID 68943-Chloro-2-methylanilineHCID 2320651-Acetamido-5,6,7,8-tetrahydronaphthaleneHCID 12710300N-(4-Bromo-5,6,7,8-tetrahydronaphthalen-1-yl)-acetamide

Product 1

HCID 86376N-(4-Bromo-3-chloro-2-methylphenyl)acetamideYield 96%

Procedure

The title compound was prepared (2.75 g, 96% yield) from commercially available 3-chloro-2-methylaniline by procedures analogous to those described in Experiment 2A and 2B.

Sources & evidence

ORD record
ord-673d5d16067c40da8b97fd953d0234e1
Source dataset
uspto-grants-2010_08
Patent number
US07772267B2

Linked notes

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