1,6-Dioxaspiro[2.5]octane → HCID 59255059, compound

HRID 502895Notes

Reaction equation

HRID 502895 reaction equation
[C:1]([O:5][C:6](=[O:15])[NH:7][CH2:8][CH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1)([CH3:4])([CH3:3])[CH3:2].[O:16]1[C:18]2([CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)[CH2:17]1>CO>[C:1]([O:5][C:6](=[O:15])[NH:7][CH2:8][CH:9]1[CH2:10][CH2:11][N:12]([CH2:17][C:18]2([OH:16])[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)[CH2:13][CH2:14]1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 1604391,6-Dioxaspiro[2.5]octaneHCID 723429Tert-butyl (piperidin-4-ylmethyl)carbamate

Product 1

HCID 59255059HCID 59255059, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred solution of tert-butyl(piperidin-4-ylmethyl)carbamate (22.3 g, 104 mmol) in methanol was added 1,6-dioxaspiro[2.5]octane (14.2 g, 124 mmol, Satyamurthy, Nagichettiar et al., Phosphorus Sulfur, 1984, 19, 113) at ambient temperature.

Sources & evidence

ORD record
ord-4915662e86cd4417b09f827755efa109
Source dataset
uspto-grants-2010_08
Patent number
US07776885B2

Reaction notes

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