1,12-Bis(2-amino-3,4,5,6-tetrahydropyrimidyl)dodecane dihydroiodide → 1,12-Bis(2-amino-3,4,5,6-tetrahydropyrimidyl)dodecane diacetate
Reaction equation
I.I.[NH2:3][C:4]1[N:9]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][CH2:25][N:24]=[C:23]2[NH2:28])[CH2:8][CH2:7][CH2:6][N:5]=1.[CH3:29][OH:30].[OH2:31]>>[C:29]([OH:31])(=[O:30])[CH3:4].[C:29]([OH:31])(=[O:30])[CH3:4].[NH2:3][C:4]1[N:9]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][CH2:25][N:24]=[C:23]2[NH2:28])[CH2:8][CH2:7][CH2:6][N:5]=1Participants
3
Procedure
30.0 g (0.048 mol) of 1,12-bis(2-amino-3,4,5,6-tetrahydropyrimidyl)dodecane dihydroiodide in 300 ml of methanol/water (1:1) were filtered through a column containing 250 g of ion exchanger (OH- form). The free guanidine base obtained after working up was dissolved in methanol and converted into the diacetate with excess glacial acetic acid.
Sources & evidence
- ORD record
- ord-62caf7e77d574b0eacf847ea9cbf3833
- Source dataset
- uspto-grants-1993_09