Ammonia → 4-Amino-3,5-dichlorobenzotrifluoride

HRID 504088Notes

Reaction equation

HRID 504088 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:5]=[C:6]([Cl:9])[C:7]=1Cl.[NH3:14]>O>[Cl:1][C:2]1[CH:3]=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:5]=[C:6]([Cl:9])[C:7]=1[NH2:14]

Participants

4

Reactant 2

HCID 222Ammonia2×HCID 27333991,2,3-Trichloro-5-(trifluoromethyl)benzene

Product 1

HCID 1410944-Amino-3,5-dichlorobenzotrifluoride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Into a 1000 ml high-pressure reaction vessel add 200 g 3,4,5-Trichlorobenzotrifluoride and 145 g water, enclose the reaction vessel, fill liquid ammonia 380 g, close the valve, start agitation, slowly increase temperature to 160° C. and pressure to 10.0 MPa, make timed temperature-retention under controlled temperature 165° C. and controlled pressure 11.5 MPa for 8 h, then release the pressure and discharge ammonia.

Workup

  1. customInto a 1000 ml high-pressure reaction vessel
  2. customclose the valve
  3. customto 160° C.
  4. customunder controlled temperature 165° C. and controlled pressure 11.5 MPa
  5. customfor 8 h

Sources & evidence

ORD record
ord-52f2556c81fd4dacbea8a61b3f3d9cef
Source dataset
uspto-grants-2010_08
Patent number
US07777079B2

Reaction notes

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