(R)-Pantothenate → Calcium pantothenate, (S)-

HRID 504990Notes

Reaction equation

HRID 504990 reaction equation
[C:1]([O-:15])(=[O:14])[CH2:2][CH2:3][NH:4][C:5](=[O:13])[C@@H:6]([C:8]([CH2:11][OH:12])([CH3:10])[CH3:9])[OH:7].[OH-].[Ca+2:17].[OH-]>>[C:1]([O-:15])(=[O:14])[CH2:2][CH2:3][NH:4][C:5](=[O:13])[C@H:6]([C:8]([CH2:11][OH:12])([CH3:10])[CH3:9])[OH:7].[Ca+2:17].[C:1]([O-:15])(=[O:14])[CH2:2][CH2:3][NH:4][C:5](=[O:13])[C@H:6]([C:8]([CH2:11][OH:12])([CH3:10])[CH3:9])[OH:7]

Participants

3

Reactant 2

HCID 167945(R)-PantothenateHCID 6093208Calcium Hydroxide

Product 1

HCID 25021359Calcium pantothenate, (S)-

Procedure

75 ml of Fraction 2 which contains 4.8 g of pantothenate were brought to a pH of 7, with stirring, by adding solid calcium hydroxide. The resultant calcium D-pantothenate solution or suspension was then dried by evaporating off water on a rotary evaporator and 8.98 g of a light-brown calcium D-pantothenate powder were obtained which has a content of 57% calcium D-pantothenate. This powder has no tendency to stick together and has good product properties.

Workup

  1. dry with materialThe resultant calcium D-pantothenate solution or suspension was then dried
  2. customby evaporating off water
  3. customon a rotary evaporator

Sources & evidence

ORD record
ord-3c7a00baef854d2886bafbe24af7a429
Source dataset
uspto-grants-2010_08
Patent number
US07781192B2

Reaction notes

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