2-Chloro-1-(4-methylpiperazin-1-yl)ethanone → 2-{6-Chloro-3-[4-(2-isopropoxy-phenyl)-piperidine-1-carbonyl]-indol-1-yl}-1-(4-methyl-piperazin-1-yl)-ethanone

HRID 505106

Reaction equation

HRID 505106 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][CH:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[O:25][CH:26]([CH3:28])[CH3:27])[CH2:15][CH2:14]3)=[O:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.Cl[CH2:30][C:31]([N:33]1[CH2:38][CH2:37][N:36]([CH3:39])[CH2:35][CH2:34]1)=[O:32]>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][CH:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[O:25][CH:26]([CH3:28])[CH3:27])[CH2:15][CH2:14]3)=[O:12])=[CH:7][N:8]2[CH2:30][C:31]([N:33]2[CH2:38][CH2:37][N:36]([CH3:39])[CH2:35][CH2:34]2)=[O:32])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 8181732-Chloro-1-(4-methylpiperazin-1-yl)ethanoneHCID 59429630HCID 59429630, compound

Product 1

HCID 160625752-{6-Chloro-3-[4-(2-isopropoxy-phenyl)-piperidine-1-carbonyl]-indol-1-yl}-1-(4-methyl-piperazin-1-yl)-ethanone

Procedure

Following general procedure II, the alkylation of (6-chloro-1H-indol-3-yl)-[4-(2-isopropoxy-phenyl)-piperidin-1-yl]-methanone (preparation described herein), with (commercially available) 2-chloro-1-(4-methyl-piperazin-1-yl)-ethanone gave the title compound.

Sources & evidence

ORD record
ord-84e642fd5c4f42e6abe56fa1819d010a
Source dataset
uspto-grants-2010_08
Patent number
US07781436B2

Linked notes

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