4-Pyridin-2-ylbenzaldehyde → 3-(Quinolin-7-yl)prop-2-enal

HRID 50570

Reaction equation

[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH:11]=O)[CH:9]=2)[CH:4]=[CH:3][CH:2]=1.N1C=CC=CC=1C1C=C[C:22]([CH:23]=[O:24])=CC=1>>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8](/[CH:11]=[CH:22]/[CH:23]=[O:24])[CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 15152404-Pyridin-2-ylbenzaldehyde

HCID 47122557-Quinolinecarboxaldehyde

Product 1

HCID 226311883-(Quinolin-7-yl)prop-2-enal

Procedure

The title compound was prepared by a procedure analogous to Reference Example 31 by substituting 7-quinolinecarboxaldehyde (prepared as described in J. Med. Chem. 1993, 36, 3308) for the 4-(2-pyridinyl)-benzaldehyde of Reference Example 31. MS 184 (M+H)+.

Sources & evidence

ORD record: ord-13bd3e640ffe45808037060db7d2129b
Source dataset: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06713455B2

Linked notes

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