1-(5-Nitropyridin-2-yl)azetidin-3-ol → 1-(5-Aminopyridin-2-yl)azetidin-3-ol
Reaction equation
[OH:1][CH:2]1[CH2:5][N:4]([C:6]2[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][N:7]=2)[CH2:3]1>[Pd]>[OH:1][CH:2]1[CH2:3][N:4]([C:6]2[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][N:7]=2)[CH2:5]1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
The process is carried out according to the method described in step 5.2, using 5.5 g (28.18 mmol) of 2-(3-hydroxyazetidin-1-yl)-5-nitropyridine, prepared in step 10.1, and 0.5 g of 10% palladium-on-charcoal. 4.5 g of the expected product are thus obtained in the form of violet crystals.
Sources & evidence
- ORD record
- ord-ff0aa1d8592a40d4acc2966528d09658
- Source dataset
- uspto-grants-2010_08
- Patent number
- US07786104B2
Reaction notes
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