Eltoprazine → 3-{4-[4-(2,3-Dihydrobenzo[1,4]dioxin-5-yl)-piperazin-1-yl]-butyl}-3-ethyl-1,3-dihydro-2H-indol-2-one

HRID 506904Notes

Reaction equation

HRID 506904 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][C:6]1([CH2:16][CH3:17])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][C:7]1=[O:15].[O:18]1[C:23]2[CH:24]=[CH:25][CH:26]=[C:27]([N:28]3[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]3)[C:22]=2[O:21][CH2:20][CH2:19]1>>[O:18]1[C:23]2[CH:24]=[CH:25][CH:26]=[C:27]([N:28]3[CH2:33][CH2:32][N:31]([CH2:2][CH2:3][CH2:4][CH2:5][C:6]4([CH2:16][CH3:17])[C:14]5[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=5)[NH:8][C:7]4=[O:15])[CH2:30][CH2:29]3)[C:22]=2[O:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 65853EltoprazineHCID 670406333-(4-Chlorobutyl)-3-ethyl-1,3-dihydro-2H-indol-2-one

Product 1

HCID 684669843-{4-[4-(2,3-Dihydrobenzo[1,4]dioxin-5-yl)-piperazin-1-yl]-butyl}-3-ethyl-1,3-dihydro-2H-indol-2-one

Procedure

The title compound is prepared according to process H by applying processing method 1 starting from 3-(4-chlorobutyl)-3-ethyl-1,3-dihydro-2H-indol-2-one and 4-(2,3-dihydrobenzo[1,4]dioxin-5-yl)-piperazine.

Sources & evidence

ORD record
ord-4d20cf5420e147aab48e2f4289f3cc27
Source dataset
uspto-grants-2010_08
Patent number
US07786129B2

Reaction notes

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