HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-fluoroanisole → 6-(3-Fluoro-4-methoxy-phenyl)4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-fluoroanisole | HCID 75378 | — |
| Reactant | (4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)boronic acid | HCID 10987806 | — |
| Product | 6-(3-Fluoro-4-methoxy-phenyl)4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one | HCID 23509640 | — |
Reaction Steps
Prepared according to procedure B from 4-bromo-2-fluoroanisole and (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid. White solid: mp 210-211° C. 1H-NMR (DMSO-d6), δ 10.27(s, 1H), 7.52-7.60 (m, 3H), 7.45(d, 1H, J=8.6 Hz), 7.22 (t, 1H, J=8.9 Hz), 6.94 (d, 1H, J=8.8 Hz), 3.87 (s, 3H), 1.66 (s, 6H). MS [M−H]−m/z=300 Anal. Calc. For C17H16FNO3: C, 67.76; H, 5.35; N, 4.65. Found: C, 67.88; H, 5.39; N, 4.70.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06713478B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-d6bb6bf824944e02945236763d337d27 |
| Source note | uspto-grants-2004_03 |