2-Chlorothiophene → 5-Bromo-2-chloro-4-(5-chlorothiophen-2-yl)pyrimidine

HRID 507577Notes

Reaction equation

[Cl:1][C:2]1[S:3][CH:4]=[CH:5][CH:6]=1.[Br:7][C:8]1[CH:9]=[N:10][C:11]([Cl:14])=[N:12][CH:13]=1>>[Br:7][C:8]1[C:9]([C:4]2[S:3][C:2]([Cl:1])=[CH:6][CH:5]=2)=[N:10][C:11]([Cl:14])=[N:12][CH:13]=1

Participants

Reactant 2

HCID 72992-Chlorothiophene

HCID 6066655-Bromo-2-chloropyrimidine

Product 1

HCID 574288335-Bromo-2-chloro-4-(5-chlorothiophen-2-yl)pyrimidine

Procedure

The title compound was prepared from 2-chlorothiophene and 5-bromo-2-chloropyrimidine in a manner analogous to Example 249, Step 1. MS (M+H)+ 311.

Sources & evidence

ORD record: ord-9eb8ac8b9d8d4b9997f801db8a1e42d9
Source dataset: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07786132B2

Reaction notes

Loading…