HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (E)-1-(6-Methylpyrid-2-yl)-2-styryl-1H-benzimidazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 6-Chloro-2-picoline | HCID 87601 | — |
| Reactant | 2-(2-Phenylethenyl)-1h-benzimidazole | HCID 242965 | — |
| Reactant | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (E)-1-(6-Methylpyrid-2-yl)-2-styryl-1H-benzimidazole hydrochloride | HCID 22736649 | — |
Reaction Steps
Free base of the titled compound was prepared from 2-styryl-1H-benzimidazole and 2-Chloro-6-methylpyridine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base was treated with a 10% methanol solution of hydrogen chloride and concentrated to dryness. The residue was recrystallized from ethyl acetate/n-hexane to give the titled compound. MW: 347.85; mp: 216.0-217.0° C.; 1H-NMR (DMSO-d6) δ: 8.20 (1H, br s), 8.10 (1 H, t, J=7.7 Hz), 7.87 (1H, d, J=7.7 Hz), 7.71-7.44 (10H, m), 7.22 (1H, d, J=16.1 Hz), 2.63 (3H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06713482B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-3a8120cb18b04255baa1d1cdaaa70be9 |
| Source note | uspto-grants-2004_03 |