Dichloromethane → (4-Benzenesulphonyl-phenyl)-(6-(5-((2-methylthio-ethylamino)-methyl)-furan-2-yl)-pyrido[3,4-d]pyrimidin-4-yl)-amine Dihydrochloride

HRID 51143

Reaction equation

HRID 51143 reaction equation
[C:1]1([S:7]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17]3[C:18]4[CH:26]=[C:25]([C:27]5[O:31][C:30]([CH:32]=O)=[CH:29][CH:28]=5)[N:24]=[CH:23][C:19]=4[N:20]=[CH:21][N:22]=3)=[CH:12][CH:11]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:34][S:35][CH2:36][CH2:37][NH2:38].[Cl:39]CCl>>[ClH:39].[ClH:39].[C:1]1([S:7]([C:10]2[CH:11]=[CH:12][C:13]([NH:16][C:17]3[C:18]4[CH:26]=[C:25]([C:27]5[O:31][C:30]([CH2:32][NH:38][CH2:37][CH2:36][S:35][CH3:34])=[CH:29][CH:28]=5)[N:24]=[CH:23][C:19]=4[N:20]=[CH:21][N:22]=3)=[CH:14][CH:15]=2)(=[O:8])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 87697(2-(Methylthio)ethyl)amineHCID 219519165-(4-((4-Benzenesulphonyl-phenyl)amino)-pyrido[3,4-d]pyrimidin-6-yl)-furan-2-carbaldehyde

Product 1

HCID 21952258(4-Benzenesulphonyl-phenyl)-(6-(5-((2-methylthio-ethylamino)-methyl)-furan-2-yl)-pyrido[3,4-d]pyrimidin-4-yl)-amine Dihydrochloride

Procedure

5-(4-((4-Benzenesulphonyl-phenyl)amino)-pyrido[3,4-d]pyrimidin-6-yl)-furan-2-carbaldehyde (250 mg) and (methylthio)ethylamine (185 mg)) in dichloromethane (5 ml) were reacted together as in Procedure D. Purification using a Bond Elut™ cartridge, gave a yellow solid (245 mg), 70 mg of which was converted to the hydrochloride salt, (yellow solid, 68 mg); m/z 532 (M+1)+.

Workup

  1. customPurification

Sources & evidence

ORD record
ord-331cced63d0d45029817401f01bbd768
Source dataset
uspto-grants-2004_03
Patent number
US06713485B2

Linked notes

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