2-(Methylsulfonyl)ethanamine → Lapatinib

Participants

Role	Name	HCID	Charge
Reactant	2-(Methylsulfonyl)ethanamine	HCID 4340561	—
Reactant	(5-(4-(4-((3-Fluorobenzyl)oxy)-3-chloroanilino)-6-quinazolinyl)-2-furancarboxaldehyde	HCID 11181296	—
Product	Lapatinib	HCID 208908	—

Reaction Steps

Prepared according to Procedure D from 5-(4-{3-chloro-4-(3-fluorobenzyloxy)-anilino}-6-quinazolinyl)-furan-2-carbaldehyde (0.6 equiv) and 2-methanesulphonyl-ethylamine (1 equiv). 1H NMR 400 MHz (DMSO-d6) 9.60 (bs, 1H); 9.32 (bs, 1H); 8.82 (bs, 1H); 8.34 (d, 1H); 8.0 (s, 1H); 7.88 (d, 1H); 7.74 (d, 1H); 7.45 (m, 1H); 7.34-7.23 (m, 4H); 7.17 (m, 1H); 6.83 (d, 1H); 5.27 (s, 2H); 4.42 (s, 2H); 3.59 (m, 2H); 3.40 (m, 2H, obscured by waterpeak); 3.12 (s, 3H); MS m/z 581 (M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06713485B2
Source dataset	uspto-grants-2004_03
ORD ID	ord-ba7c9aa36a4542e9891af4ebd28194f0
Source note	uspto-grants-2004_03