3-Fluoro-2-methylbenzoic acid → N-[4,4-Difluoro-1-(6-trifluoromethyl-pyridin-3-yl)-cyclohexylmethyl]-3-fluoro-2-methyl-benzamide
Reaction equation
[F:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=O.[F:12][C:13]1([F:31])[CH2:18][CH2:17][C:16]([CH2:29][NH2:30])([C:19]2[CH:20]=[N:21][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:23][CH:24]=2)[CH2:15][CH2:14]1>>[F:31][C:13]1([F:12])[CH2:14][CH2:15][C:16]([CH2:29][NH:30][C:5](=[O:7])[C:4]2[CH:8]=[CH:9][CH:10]=[C:2]([F:1])[C:3]=2[CH3:11])([C:19]2[CH:20]=[N:21][C:22]([C:25]([F:26])([F:27])[F:28])=[CH:23][CH:24]=2)[CH2:17][CH2:18]1Participants
3
Procedure
From 3-fluoro-2-methylbenzoic acid and C-[4,4-difluoro-1-(6-trifluoromethyl-pyridin-3-yl)-cyclohexyl]-methylamine. LCMS (MH+): m/z=431.2, tR (minutes, Method D)=0.79
Sources & evidence
- ORD record
- ord-3bef47d24e07471c8a20338cc9d70e82
- Source dataset
- uspto-grants-2015_08
- DOI