4-Cyano-3-fluorobenzyl bromide → 1-(4-Cyano-3-fluoro-benzyl)-2-methyl-4-oxo-2'-trifluoromethyl-1,4-dihydro-[3,4']bipyridinyl-5-carboxylic acid methylamide
Reaction equation
Br[CH2:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[C:5]([F:11])[CH:4]=1.[CH3:12][NH:13][C:14]([C:16]1[C:17](=[O:33])[C:18]([C:23]2[CH:28]=[CH:27][N:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:24]=2)=[C:19]([CH3:22])[NH:20][CH:21]=1)=[O:15]>>[CH3:12][NH:13][C:14]([C:16]1[C:17](=[O:33])[C:18]([C:23]2[CH:28]=[CH:27][N:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:24]=2)=[C:19]([CH3:22])[N:20]([CH2:2][C:3]2[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[C:5]([F:11])[CH:4]=2)[CH:21]=1)=[O:15]Participants
3
Reactant 2
Product 1
Procedure
Example 43 is prepared as described for example 2.1, substituting benzyl bromide with 4-bromomethyl-2-fluoro-benzonitrile and substituting preparation 5 with preparation 36a. ESI mass spectrum: [M+H]+=445; Retention time HPLC: 0.97 min (Z018_S04).
Workup
- custom