Ethanolamine → Palmitoylethanolamide

HRID 5127

Reaction equation

HRID 5127 reaction equation
[NH2:1][CH2:2][CH2:3][OH:4].[C:5](Cl)(=[O:21])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]>C(Cl)(Cl)Cl>[C:5]([NH:1][CH2:2][CH2:3][OH:4])(=[O:21])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 8206Palmitoyl chloride

Product 1

HCID 4671Palmitoylethanolamide

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

2-Aminoethanol (13.76 g, 225.3 mmol) was dissolved in CHCl3 (750 ml). To the solution was added dropwise palmitoyl chloride (15.48 g, 56.3 mmol) with stirring under ice cooling. Thereafter, the mixture was stirred at room temperature for 19 hours.

Workup

  1. stirringThereafter, the mixture was stirred at room temperature for 19 hours

Sources & evidence

ORD record
ord-dcadfe0e1eca4e47a8b88dad58fe8309
Source dataset
uspto-grants-1993_09
Patent number
US05243035

Linked notes

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