3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine → 1-(1-(6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3-yl)piperidin-4-yl)indoline
Reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH2:10][CH2:9]2)[CH2:4][CH2:3]1.Cl[C:18]1[N:19]=[N:20][C:21]([C:24]2[CH:25]=[N:26][N:27]([CH3:29])[CH:28]=2)=[CH:22][CH:23]=1>>[CH3:29][N:27]1[CH:28]=[C:24]([C:21]2[N:20]=[N:19][C:18]([N:2]3[CH2:7][CH2:6][CH:5]([N:8]4[C:16]5[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=5)[CH2:10][CH2:9]4)[CH2:4][CH2:3]3)=[CH:23][CH:22]=2)[CH:25]=[N:26]1Participants
3
Procedure
The title compound was prepared according to the procedure as described in Example 1, Method B, reacting 1-(piperidin-4-yl)indoline HCl salt and 3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine.
Sources & evidence
- ORD record
- ord-04745cd43b994958a319fc7ad9b8e1fd
- Source dataset
- uspto-grants-2015_08