Iodine → 6-Chloro-2-iodopyridin-3-amine

Temperature

20 °C

To a solution of 6-chloro-pyridin-3-ylamine (10.0 g, 77.8 mmol) in EtOH (150 mL) was added Ag2SO4 (12.1 g, 38.9 mmol) and I2 (23.7 g, 93.4 mmol) at room temperature. The mixture was stirred at 20° C. overnight. The solvent was removed by evaporation under vacuum. Water (100 mL) and EtOAc (200 mL) were added to the residue. The organic layer was separated and the aqueous layer was extracted with EtOAc (100 mL×3). The combined organic layers were dried over anhydrous Na2SO4 and evaporated under vacuum to give the crude product, which was purified by column chromatography on silica gel (Petroleum ether/Ethyl acetate 7:1) to give 6-chloro-2-iodo-pyridin-3-ylamine (17.1 g, 86%). 1H NMR (DMSO, 300 MHz) δ 7.16 (d, J=8.4 Hz, 1H), 7.01 (d, J=8.4 Hz, 1H), 5.57 (s, 2H).

1. customThe solvent was removed by evaporation under vacuum
2. additionWater (100 mL) and EtOAc (200 mL) were added to the residue
3. customThe organic layer was separated
4. extractionthe aqueous layer was extracted with EtOAc (100 mL×3)
5. dry with materialThe combined organic layers were dried over anhydrous Na2SO4
6. customevaporated under vacuum
7. customto give the crude product, which
8. customwas purified by column chromatography on silica gel (Petroleum ether/Ethyl acetate 7:1)

ORD record

ord-df791a2e39074c7ca9e7896999ccfcac

Source dataset

uspto-grants-2015_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09102672B2