HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 11H-12-Thia-1,10,11-triaza-chrysene 12,12-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Tert-Butyl nitrite | HCID 10906 | — |
| Reactant | 3-Amino-pyridine-2-sulfonic acid quinolin-8-ylamide | HCID 68183136 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 11H-12-Thia-1,10,11-triaza-chrysene 12,12-dioxide | HCID 68183509 | 7.1% |
Reaction Steps
In a similar fashion using route 16 general procedure 61, using 3-amino-pyridine-2-sulfonic acid quinolin-8-ylamide (Intermediate 303) (180 mg, 0.6 mmol), t-butyl nitrite (0.11 ml, 0.9 mmol), AcOH (1.8 ml) and THF(1.8 ml) gave the title compound (12 mg, 7%) after purification with prep HPLC (neutral conditions).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-8af1baa5bee5406a897ccc1e59dbee1f |
| Source note | uspto-grants-2015_08 |