4-Amino-6-bromo-2-methylpyrimidine → Isopropyl 2-(6-bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formate

Reaction equation

Cl[C:2]1[S:3][C:4]([C:7]([O:9][CH:10]([CH3:12])[CH3:11])=[O:8])=[CH:5][N:6]=1.[NH2:13][C:14]1[CH:19]=[C:18]([Br:20])[N:17]=[C:16]([CH3:21])[N:15]=1>>[Br:20][C:18]1[N:17]=[C:16]([CH3:21])[N:15]=[C:14]([NH:13][C:2]2[S:3][C:4]([C:7]([O:9][CH:10]([CH3:12])[CH3:11])=[O:8])=[CH:5][N:6]=2)[CH:19]=1

Participants

Reactant 2

HCID 569657194-Amino-6-bromo-2-methylpyrimidine

HCID 71082669Isopropyl 2-chlorothiazole-5-formate

Product 1

HCID 49821808Isopropyl 2-(6-bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formateYield 76.9%

Procedure

Prepared from isopropyl 2-chlorothiazole-5-formate and Compound 9: isopropyl 2-(6-bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formate was yielded (yield: 76.9%).

Sources & evidence

ORD record: ord-27abd74500c147c79bcd8e6da2ca0dc2
Source dataset: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09108954B2

Reaction notes

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