Water → Benzeneacetic acid, 3,5-dichloro-, methyl ester

Reaction equation

Cl.[Cl:2][C:3]1[CH:4]=[C:5]([CH2:10][C:11](=N)[O:12][CH3:13])[CH:6]=[C:7]([Cl:9])[CH:8]=1.C1(C)C=CC=CC=1.[OH2:22]>>[Cl:2][C:3]1[CH:4]=[C:5]([CH2:10][C:11]([O:12][CH3:13])=[O:22])[CH:6]=[C:7]([Cl:9])[CH:8]=1

Participants

Reactant 3

HCID 962Water

HCID 1140Toluene

HCID 722112961196155-85-7

Product 1

HCID 67195643Benzeneacetic acid, 3,5-dichloro-, methyl esterYield 91%

Procedure

To methyl 3,5-dichlorobenzeneethanimidate hydrochloride (1:1) (i.e. the product from Step A1a) (50 g, 0.107 mol) was added to a mixture of toluene (167 mL) and water (167 mL). After 60 min the organic phase was removed, dried (MgSO4), and evaporated to give the title compound as an oil (39 g, 91%).