5-Hydroxymethyl-3-furancarboxylic acid ethyl ester → Ethyl 5-formylfuran-3-carboxylate
Reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[C:9]([CH2:11][OH:12])[O:8][CH:7]=1)=[O:5])[CH3:2]>ClCCl.[O-2].[O-2].[Mn+4]>[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[C:9]([CH:11]=[O:12])[O:8][CH:7]=1)=[O:5])[CH3:2]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
5-Hydroxymethyl-3-furancarboxylic acid ethyl ester (0.34 g, 2.0 mmol) was dissolved in dichloromethane (20 mL), manganese dioxide (1.4 g, 15.9 mmol) was added, and the mixture was stirred overnight. The reaction mixture was filtered through celite, and the solvent was evaporated under reduced pressure to give the title compound (0.26 g).
Workup
- filtrationThe reaction mixture was filtered through celite
- customthe solvent was evaporated under reduced pressure
Sources & evidence
- ORD record
- ord-7d3c0bbc56df4919b4ce57b29826c92d
- Source dataset
- uspto-grants-2015_08
- Patent number
- US09115107B2
Reaction notes
Loading…