(S)-3-amino-2-[4-(4-fluorobenzyl)piperazin-1-yl]propanoate trihydrochloride → methyl (S)-3-amino-2-[4-(4-fluorobenzyl)piperazin-1-yl]propanoate trihydrochloride

HRID 517523

Reaction equation

HRID 517523 reaction equation
C(OC([NH:8][CH2:9][C@H:10]([N:15]1[CH2:20][CH2:19][N:18]([CH2:21][CH3:22])[CH2:17][CH2:16]1)[C:11]([O:13][CH3:14])=[O:12])=O)(C)(C)C.[ClH:23].Cl.Cl.NC[C@H](N1CCN(CC2[CH:44]=[CH:43][C:42]([F:45])=[CH:41][CH:40]=2)CC1)C(O)=O>>[ClH:23].[ClH:23].[ClH:23].[NH2:8][CH2:9][C@H:10]([N:15]1[CH2:16][CH2:17][N:18]([CH2:21][C:22]2[CH:44]=[CH:43][C:42]([F:45])=[CH:41][CH:40]=2)[CH2:19][CH2:20]1)[C:11]([O:13][CH3:14])=[O:12]

Participants

3

Reactant 2

HCID 68088326(S)-3-amino-2-[4-(4-fluorobenzyl)piperazin-1-yl]propanoate trihydrochlorideHCID 86667916methyl (S)-3-tert-butoxycarbonylamino-2-(4-ethylpiperazin-1-yl)propanoate

Product 1

HCID 86667914methyl (S)-3-amino-2-[4-(4-fluorobenzyl)piperazin-1-yl]propanoate trihydrochloride

Procedure

In a manner similar to example 2-3, starting from 5.3 g (13.4 mmol) of methyl (S)-3-tert-butoxycarbonylamino-2-(4-ethylpiperazin-1-yl)propanoate, 5.4 g (100%) of (S)-3-amino-2-[4-(4-fluorobenzyl)piperazin-1-yl]propanoate trihydrochloride are obtained in the form of a beige solid.

Workup

  1. customare obtained in the form of a beige solid

Sources & evidence

ORD record
ord-363887cf31a64b979487d6a423891139
Source dataset
uspto-grants-2015_08
Patent number
US09115102B2

Linked notes

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