1H-1,2,4-Triazole-1-ethanol → HCID 178457863, compound

HRID 518697

Reaction equation

HRID 518697 reaction equation
[N:1]1([CH2:6][CH2:7][OH:8])[CH:5]=[N:4][CH:3]=[N:2]1.[CH:9]([NH:12][C:13]([C@H:15]1[CH2:20][CH2:19][C@@H:18]([NH:21][C:22]2[C:27]([N+:28]([O-:30])=[O:29])=[CH:26][N:25]=[C:24](OCCOC)[CH:23]=2)[CH2:17][CH2:16]1)=[O:14])([CH3:11])[CH3:10]>>[N:1]1([CH2:6][CH2:7][O:8][C:24]2[CH:23]=[C:22]([NH:21][C@@H:18]3[CH2:19][CH2:20][C@H:15]([C:13]([NH:12][CH:9]([CH3:11])[CH3:10])=[O:14])[CH2:16][CH2:17]3)[C:27]([N+:28]([O-:30])=[O:29])=[CH:26][N:25]=2)[CH:5]=[N:4][CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 5509251H-1,2,4-Triazole-1-ethanolHCID 178496145HCID 178496145, compound

Product 1

HCID 178457863HCID 178457863, compound

Procedure

Intermediate cis-4-(2-(2-(1H-1,2,4-triazol-1-yl)ethoxy)-5-nitropyridin-4-ylamino)-N-isopropylcyclohexanecarboxamide was prepared in 2 steps from 2-(1H-1,2,4-triazol-1-yl)ethanol using a procedure analogous to that used to prepare cis-N-isopropyl-4-(2-(2-methoxyethoxy)-5-nitropyridin-4-ylamino)cyclohexanecarboxamide (104 mg).

Sources & evidence

ORD record
ord-2270281eabdc4bc48503fee4acd52161
Source dataset
uspto-grants-2015_08
Patent number
US09115127B2

Linked notes

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