Dimedone → 3-Acetylamino-5-[(4,6-dimethoxypyrimidin-2yl)oxy]-2-methylindol-4-carboxylic Acid

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Reaction Steps

0.49 g of allyl 3-acetylamino-5-[(4,6-dimethoxypyrimidin-2-yl)oxy]-2-methylindol-4-carboxylate was dissolved in 10 ml of tetrahydrofuran, and 0.1 g of dimedone and 0.01 g of tetrakistriphenylphosphine palladium were added thereto. The mixture was stirred at room temperature for 4 hours. Crystals obtained by concentration under reduced pressure, was washed with isopropyl ether to obtain 0.41 g (yield: 93%) of the desired compound. mp: 230°-233° C.

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