2-Mercaptoethanol → N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-4-(2-hydroxyethylthio)butyramide

HRID 52049

Reaction equation

HRID 52049 reaction equation
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH:19][C:20](=[O:25])[CH2:21][CH2:22][CH2:23]Cl)[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[SH:26][CH2:27][CH2:28][OH:29]>>[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH:19][C:20](=[O:25])[CH2:21][CH2:22][CH2:23][S:26][CH2:27][CH2:28][OH:29])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 15672-MercaptoethanolHCID 67726214N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-4-chlorobutyramide

Product 1

HCID 67725591N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-4-(2-hydroxyethylthio)butyramideYield 66%

Procedure

Following a procedure similar to that described in Example 1, but using N-[4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenyl]-4-chlorobutyramide (prepared as described in Preparation 2) and 2-mercaptoethanol as starting materials, in relative proportions similar to those used in that Example, and carrying out the reaction at 80° C. for 5 hours, the title compound was obtained in a 66% yield.

Workup

  1. customthe reaction at 80° C. for 5 hours

Sources & evidence

ORD record
ord-d2b2d96dd1ab4d00b20e980386f6c29d
Source dataset
uspto-grants-1997_04
Patent number
US05616579

Linked notes

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