Pyrazole-4-carboxylic acid → N-[5-(4-Piperidinomethyl-2-pyridyloxy)pentyl]pyrazole-4-carboxamide

HRID 52093

Reaction equation

HRID 52093 reaction equation
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH2:20])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:21]1[CH:25]=[C:24]([C:26](O)=[O:27])[CH:23]=[N:22]1>>[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:26]([C:24]3[CH:25]=[N:21][NH:22][CH:23]=3)=[O:27])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 3015937Pyrazole-4-carboxylic acidHCID 199629605-(4-Piperidinomethyl-2-pyridyloxy)pentylamine

Product 1

HCID 19962872N-[5-(4-Piperidinomethyl-2-pyridyloxy)pentyl]pyrazole-4-carboxamide

Procedure

Following a procedure similar to that described in Example 64, but using 5-(4-piperidinomethyl-2-pyridyloxy)pentylamine and 4-pyrazolecarboxylic acid as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as a white powder, melting at 105°-106° C., in a yield.

Sources & evidence

ORD record
ord-b9ac4fcb13d44f7bb766514a6dabe55f
Source dataset
uspto-grants-1997_04
Patent number
US05616579

Linked notes

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