Ammonium Chloride → Methyl 2-(((2-amino-4-methylphenyl)thio)methyl)benzoate
Reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][C:10]2[CH:19]=[CH:18][CH:17]=[CH:16][C:11]=2[C:12]([O:14][CH3:15])=[O:13])=[C:4]([N+:20]([O-])=O)[CH:3]=1.[NH4+].[Cl-]>CO.[Zn]>[NH2:20][C:4]1[CH:3]=[C:2]([CH3:1])[CH:7]=[CH:6][C:5]=1[S:8][CH2:9][C:10]1[CH:19]=[CH:18][CH:17]=[CH:16][C:11]=1[C:12]([O:14][CH3:15])=[O:13]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
Following General Procedure L, the title compound (567 mg, 85%) was prepared from methyl 2-(((4-methyl-2-nitrophenyl)thio)methyl)benzoate (741 mg, 2.34 mmol), Zn (3.7 g, 58.44 mmol) and saturated aqueous NH4Cl (1 ml) in MeOH (20 ml).
Sources & evidence
- ORD record
- ord-37405aeeb4c445f181fa3b369f73e581
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09328067B2
Reaction notes
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