Acetic Anhydride → N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-5-(2-acetoxyethylthio)pentanamide

HRID 52105Notes

Reaction equation

HRID 52105 reaction equation
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH:19][C:20](=[O:29])[CH2:21][CH2:22][CH2:23][CH2:24][S:25][CH2:26][CH2:27][OH:28])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:30](OC(=O)C)(=[O:32])[CH3:31]>>[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH:19][C:20](=[O:29])[CH2:21][CH2:22][CH2:23][CH2:24][S:25][CH2:26][CH2:27][O:28][C:30](=[O:32])[CH3:31])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 67725636N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-5-(2-hydroxyethylthio)pentanamide

Product 1

HCID 67726287N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-5-(2-acetoxyethylthio)pentanamideYield 92%

Procedure

Following a procedure similar to that described in Example 67(c), but using N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-5-(2-hydroxyethylthio)pentanamide [prepared as described in step (c) above] and acetic anhydride as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as an oil in a 92% yield.

Sources & evidence

ORD record
ord-0cbd77638f9f47458ca28608a83435df
Source dataset
uspto-grants-1997_04
Patent number
US05616579

Reaction notes

Loading…