2-Methyl-3-furoic acid → N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-2-methylfuran-3-carboxamide

HRID 52124

Reaction equation

HRID 52124 reaction equation
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH2:19])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:20][C:21]1[O:22][CH:23]=[CH:24][C:25]=1[C:26](O)=[O:27]>>[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH:19][C:26]([C:25]3[CH:24]=[CH:23][O:22][C:21]=3[CH3:20])=[O:27])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 2447562-Methyl-3-furoic acidHCID 136724732-Buten-1-amine, 4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-, (Z)-

Product 1

HCID 67725818N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-2-methylfuran-3-carboxamideYield 77%

Procedure

Following a procedure similar to that described in Example 13, but using 4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenylamine and 2-methylfuran-3-carboxylic acid as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as an oil in a 77% yield.

Sources & evidence

ORD record
ord-8438fe9529a14e12b0195cba9d934ffa
Source dataset
uspto-grants-1997_04
Patent number
US05616579

Linked notes

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