(2-(Difluoromethyl)phenyl)boronic acid → 2-(2-(Difluoromethyl)phenyl)thiazole-4-carboxylic acid
Reaction equation
F[C:2]1[CH:7]=[C:6](OC)[CH:5]=[C:4](F)[C:3]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1.[F:19][CH:20]([F:30])C1C=CC=CC=1B(O)O>>[F:19][CH:20]([F:30])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1Participants
3
Procedure
Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with (2-(difluoromethyl)phenyl)boronic acid gave the title compound.
Sources & evidence
- ORD record
- ord-bfcf490ec5674ee5a0a00ee421a24d5d
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09328106B2
Reaction notes
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