(2-Chloro-3-fluorophenyl)boronic acid → 2-(2-Chloro-3-fluorophenyl)thiazole-4-carboxylic acid

Reaction equation

FC1C=C(OC)C=C(F)C=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1.[Cl:19][C:20]1[C:25]([F:26])=[CH:24][CH:23]=[CH:22][C:21]=1B(O)O>>[Cl:19][C:20]1[C:25]([F:26])=[CH:24][CH:23]=[CH:22][C:21]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1

Participants

Reactant 2

HCID 22309459(2-Chloro-3-fluorophenyl)boronic acid

HCID 834100432-(2,6-Difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid

Product 1

HCID 833185872-(2-Chloro-3-fluorophenyl)thiazole-4-carboxylic acid

Procedure

Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with (2-chloro-3-fluorophenyl)boronic acid gave the title compound.

Sources & evidence

ORD record: ord-aab714d220784f3992b8a4ac34e4f964
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09328106B2

Reaction notes

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