2-{1-[(6-fluoro-2-pyridinyl)methyl]-1H-pyrazol-3-yl}-1H-isoindole-1,3(2H)-dione → 1-[(6-fluoro-2-pyridinyl)methyl]-1H-pyrazol-3-amine
Reaction equation
FC1C(CN2C=CC(N)=N2)=CC=CN=1.[F:15][C:16]1[N:21]=[C:20]([CH2:22][N:23]2[CH:27]=[CH:26][C:25]([N:28]3C(=O)C4C(=CC=CC=4)C3=O)=[N:24]2)[CH:19]=[CH:18][CH:17]=1>>[F:15][C:16]1[N:21]=[C:20]([CH2:22][N:23]2[CH:27]=[CH:26][C:25]([NH2:28])=[N:24]2)[CH:19]=[CH:18][CH:17]=1Participants
3
Procedure
Title compound was prepared by a method analogous to that described for Intermediate 47, replacing Intermediate 46 with Intermediate 45 (90 mg, 0.279 mmol) to yield the title compound (48 mg, 0.250 mmol, 48% yield). 1H NMR (300 MHz, CDCl3) δ ppm: 7.73 (q, 1H), 7.30 (d, 1H), 6.89 (dd, 1H), 6.83 (dd, 1H), 5.67 (d, 1H), 5.16 (s, 2H), 2.87 (br s, 2H). [ES+MS] m/z 192 (MH+).
Workup
- custom