1,4-Dioxane hydrochloride → 5-(2-Fluorophenoxy)-2-(1-piperazinyl)pyrimidine hydrochloride
Reaction equation
[F:1][C:2]1[CH:27]=[CH:26][CH:25]=[CH:24][C:3]=1[O:4][C:5]1[CH:6]=[N:7][C:8]([N:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)=[N:9][CH:10]=1.[ClH:28].O1CCOCC1>O1CCOCC1>[ClH:28].[F:1][C:2]1[CH:27]=[CH:26][CH:25]=[CH:24][C:3]=1[O:4][C:5]1[CH:6]=[N:7][C:8]([N:11]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]2)=[N:9][CH:10]=1Participants
4
Procedure
To a solution of tert-butyl 4-(5-(2-fluorophenoxyl)pyrimidin-2-yl)piperazine-1-carboxylate (50 mg, 0.13 mmol) in dioxane (3 mL) was added 4 M HCl/dioxane (3 mL). The reaction mixture was stirred at room temperature overnight and then concentrated to dryness. The residue (50 mg, yellow solid) was directly used in the next reaction.