3-Chloropropionitrile → 2-(2-Cyanoethyl)isothiourea monohydrochloride

HRID 523854Notes

Reaction equation

HRID 523854 reaction equation
[Cl:1][CH2:2][CH2:3][C:4]#[N:5].[NH2:6][C:7]([NH2:9])=[S:8]>O>[ClH:1].[C:4]([CH2:3][CH2:2][S:8][C:7](=[NH:6])[NH2:9])#[N:5]

Participants

4

Reactant 2

HCID 109633-ChloropropionitrileHCID 2723790Thiourea

Product 1

HCID 124175962-(2-Cyanoethyl)isothiourea monohydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The 3-chloropropanenitrile (4.32 g, 48.3 mmol) and thiourea (4.04 g, 53.1 mmol) are mixed in 40 ml of water. The mixture is heated to reflux for 3 to 4 hours. The reaction mixture is evaporated and 20 ml of ethanol is added and then evaporated as well. This is repeated three times. After that, 10 ml of methanol and 30 ml of acetone are added and the mixture is stirred for one hour. The crystalline material is filtered and the product is dried under high vacuum overnight to obtain S-(2-cyanoethyl)isothiourea hydrochloride.

Workup

  1. temperatureThe mixture is heated
  2. temperatureto reflux for 3 to 4 hours
  3. customThe reaction mixture is evaporated
  4. addition20 ml of ethanol is added
  5. customevaporated as well
  6. additionAfter that, 10 ml of methanol and 30 ml of acetone are added
  7. filtrationThe crystalline material is filtered
  8. customthe product is dried under high vacuum overnight

Sources & evidence

ORD record
ord-4a7cfdfb0fbb4f9ab71dc4809d8d9146
Source dataset
uspto-grants-2016_05
Patent number
US09340491B2

Reaction notes

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